Priming the Tumor Immune Microenvironment Improves Immune Surveillance of Cancer Stem Cells and Prevents Cancer Recurrence
Abstract
We were able to complete Specific Aim #1 of our two-aim application by extending our preliminary data. Thus, we demonstrated that our targeted elimination of cancer associated fibroblasts (CAFs) with a pFap vaccine in combination with doxorubicin (Dox) chemotherapy can prevent tumor-induced immune suppression. This, in turn, enhanced endogenous anti- tumor immunity, resulting in suppression of spontaneous metastasis and increased life span. Our findings re-emphasize the important contribution of CAFs during tumor progression, specifically during the development of tumor-mediated immune suppression. Collectively, these data add to the growing evidence supporting an integrate role for the tumor microenvironment (TME) during this process which ultimately leads to tumor cell escape from clearance by the host s immune system. Importantly, our data obtained thus far re-enforce the validity and importance of CAFs as a therapeutic target for metastatic breast cancer
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA553886
Entities
People
- Debbie Liao
- Ralph R. Reisfeld
- Yunping Luo
Organizations
- Scripps Research