Therapeutic Remyelination Strategies in a Novel Model of Multiple Sclerosis: Japanese Macaque Encephalomyelitis
Abstract
During the second year of this grant, we have finished characterizing the spontaneous form of Japanese macaque encephalomyelitis (JME) and published a manuscript in Annals of Neurology describing our results; we have characterized how intracranial injections of the Japanese macaque rhadinovirus (JMRV) induce demyelinating disease, as assessed by histopathology, MRI, and symptoms; we have demonstrated both in vitro and in vivo which cells are affected by JMRV infection; we have performed additional analyses characterizing the immune response to JMRV infection; and we have continued our genetic analyses. In the next year, we will continue to analyze the mechanisms by which JMRV triggers disease onset and immune responses and the role of the cytopathic effects of the virus in this process, which genes are linked to disease susceptibility, and how the virus influences cells in lesion microenvironments.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2011
- Accession Number
- ADA553928
Entities
People
- Betsy Ferguson
- Larry S Sherman
- Scott W. Wong
- William D. Rooney
Organizations
- Oregon Health & Science University