Mechanisms Regulating Plasma Cell Persistence in Health and Autoimmunity
Abstract
We have found that during T-dependent immune responses, nascent plasma cells express RANK ligand as one likely result of cognate interactions that occur in the absence of IL-21. We further show how this upregulation of RANKL may ultimately result in the persistence of long-lived plasma cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2011
- Accession Number
- ADA553930
Entities
People
- Michael P Cancro
Organizations
- University of Pennsylvania