Investigating a Drop-on-Demand Microdispenser for Standardized Sample Preparation
Abstract
The existing collection of reference sample preparation methods presents a range of variability and reproducibility concerns, making it increasingly difficult to assess chemical detection technologies, especially in regard to techniques that are spatially dependent. To overcome these challenges, we are examining the optimization, characterization, and calibration of microdroplets from a drop-on-demand (DOD) microdispenser that is ideal for the preparation of energetic reference materials. Current research focuses on the development of a sample preparation protocol for explosive materials testing based on DOD technology. The results presented here demonstrate the operational factors that influence droplet dispensing of specific materials (e.g., energetic and interferent). Ultraviolet-visible (UV-Vis) absorption spectroscopy and Raman spectroscopy are used to investigate droplet and sample uniformity and reproducibility (typical calibration goodness of fit R(2) values of 0.991, relative standard deviation or RSD is less than or equal to 5%). DOD results are compared to samples prepared using a drop-and-dry method.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2011
- Accession Number
- ADA554032
Entities
People
- Ellen L. Holthoff
- Keeley Q. Tober
- Mikella E. Hankus
- Paul M. Pellegrino
Organizations
- United States Army Research Laboratory