Oxidative Lung Injury in Virus-Induced Wheezing

Abstract

This project focuses on respiratory syncytial virus (RSV), the single most important pathogen causing acute respiratory-tract infections in children. RSV infections are a major precipitating factor of wheezing in asthmatic children, and they have been linked to both the development and the severity of asthma. Our group has established a multidisciplinary and highly integrated pre-clinical and translational research program that focuses on the role of oxidative injury in the pathogenesis of severe RSV infections. We have discovered that in the course of RSV infections reactive oxygen species (ROS) are rapidly generated along with viral-mediated inhibition of protective antioxidant enzyme (AOE) genes in the lung. Thus, we propose a new molecular pathway by which respiratory viruses induce lung inflammation that has implications for novel therapeutic strategies of lower respiratory infections and virus-triggered precipitation of asthma attacks.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2011
Accession Number
ADA554040

Entities

People

  • Roberto P Garofalo

Organizations

  • University of Texas at Austin

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Antigens
  • Bronchial Diseases
  • Chemistry
  • Environmental Health
  • Free Radicals
  • Health Services
  • Lung Diseases
  • Mass Spectrometry
  • Oxidative Stress
  • Proteins
  • Respiratory Tract Diseases
  • Spectra
  • Transcription Factors
  • Two Dimensional

Fields of Study

  • Biology

Readers

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  • Virology (or Medical Virology).