Deregulation of miRNAs Contributes to Development and Progression of Prostate Cancer
Abstract
This DOD grant aims to identify biomolecules that are crucial in the pathogenesis of prostate cancer. In the first year we found that miR-125b directly targets p53, Puma and Bak1. In the 2nd year, we focused on Aim 2 and have obtained exciting results: 1) miR-125b promotes prostatic tumor growth and also induces castrate-resistant growth in a mouse model; 2) miR-125-mediated suppression of apoptosis signaling contributes to the growth of CaP cells; and 3) our finding that miR-124 regulates the cellular levels of miR-125b in CaP cells provides a mechanistic explanation for up-regulation of AR/miR-125b signaling in CR CaP cells. Support from this DOD grant has lead to two published papers. One paper addresses the oncogenic activity of miR-125b in CaP cells and the other evaluates the effect of miR-106b on radiation resistance of CaP cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2011
- Accession Number
- ADA554083
Entities
People
- Ralph W. Devere White
Organizations
- University of California