Assessing the Role of Copy Number Variants in Prostate Cancer Risk and Progression Using a Novel Genome-Wide Screening Method
Abstract
Individual copy number variations in the genome may play a substantial role in influencing trait variation, yet due to technical limitations they have been understudied. We have performed the first genome-wide association of copy number variants and risk for prostate cancer in Mexican Americans. We found a highly protective deletion on 8q24 which is present in Mexican Americans but extremely rare in Caucasians. Due to the strong effect of this deletion, this discovery has implications for prostate cancer risk assessment and for understanding the etiology of prostate cancer. This variant warrants further study. We have also confirmed a deletion on 2p24 to be associated with risk for aggressive prostate cancer in non-Hispanic Caucasians and have shown that this allele is very rare in Mexican Americans and therefore not an influential factor in this population. This supports our hypothesis that heritable structural variation may affect risk for prostate cancer and/or its progression. Moreover, these variants may be unique to an ethnic population and underscores the need to investigate genetic risk in multiple populations. As genes are identified from these studies, they may prove to be both useful biomarkers for early diagnosis and/or excellent therapeutic targets for both prevention and treatment of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA554128
Entities
People
- Donna Lehman
Organizations
- University of Texas at San Antonio