Systematic Investigation of Key Survival and Growth Pathways in Breast Cancer

Abstract

We are performing proteomic studies to identify new regulators involved in the RTK/PI3K/AKT and Hippo/YAP pathways. We discovered several new regulators in these pathways, including WWP2, which targets PTEN for degradation, and AMOTL3, which associates with YAP1 and negatively regulates YAP1 activity. In the pass funding period, we also uncovered MEMO1 as an IRS1-interacting protein and showed that MEMO1 promotes epithelial-to-mesenchymal transition via regulating IRS1/Snail.. It is likely that these and other ongoing studies will reveal the roles of these interactions in breast cancer development and treatment.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA554154

Entities

People

  • Junjie Chen

Organizations

  • University of Texas at Austin

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Breast Cancer
  • Cell Membrane
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Department Of Defense
  • Epithelial Cells
  • Growth Factors
  • Intercellular Junctions
  • Neoplasms
  • Oncology
  • Polymer Chemistry
  • Proteins
  • Stem Cells

Readers

  • Oncology (Cancer Research).
  • Theoretical Analysis.

Technology Areas

  • Biotechnology