Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer
Abstract
We developed novel instrumentation and algorithm methods in response to the challenges specific to prostate cancer detection by trans-rectal fluorescence tomography imaging of the negative-uptake distribution of zinc-specific fluorophore. Specifically, we demonstrated a new configuration of swept-spectral-encoding for sequential-source-excitation in DOT that is applicable to FDOT for rapid differentiation of fluorescence excited by DC sources in the current system; we developed a new reconstruction algorithm in DOT that is extendable to FDOT for mitigating the significantly depthdependent sensitivity in trans-rectal imaging geometry for improving target localization in depth; we performed synthetic study on reconstructing negative-contrast fluorescence anomaly under spatial-prior, by a two-step region-wise FDOT reconstruction algorithm.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA554198
Entities
People
- Daqing Piao
- Guan Xu
Organizations
- Oklahoma State University–Stillwater