Immune Effects of RBC Storage in Critically III Patients
Abstract
The study aims include investigating specific mechanisms of adverse effects related to RBC storage age in critically ill patients. To ensure consistent sample and data collection in this multi-site study and to launch subject enrollment, we have standardized the procedures that are followed at each of the clinical sites. This includes coordinating IRB submissions, training clinical staff in study procedures related to sample collection, processing, and shipping. IRB approvals for the clinical sites participating in this study have been approved, and patient enrollment began in March 2011. Thus far, we have enrolled 38 patients, from whom samples have been collected, processed, shipped from Canada to San Francisco. A repository of plasma, PBMCs and whole blood samples is being built at Blood Systems Research Institute (BSRI). As we are still collecting patient samples, we have not begun cytokine testing. These tests will be performed in batches once enough samples have been obtained to minimize batch-to-batch variability in the testing results.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2011
- Accession Number
- ADA554247
Entities
People
- Philip C Spinella
Organizations
- Connecticut Children's Medical Center