Genome-Wide Association Study in African-Americans With Systemic Lupus Erythematosus

Abstract

Systemic lupus erythematosus is a potentially deadly systemic autoimmune disease that disproportionately afflicts women and African-Americans. This project is designed to discover genes that increase the risk of lupus in African-Americans. Our goal was to expand the genotyping density in African- Americans (2000 cases and 2000 controls) to increase the number and distribution of genetic markers tested. The genotyping on samples collected in Oklahoma and Birmingham is virtually complete. The control samples from Detroit have had quality and availability issues, which will be addressed in the coming year. At this time genotyping on the OMNI-1s arrays is underway. We have genotyped 2260 subjects on the OMNI-1s single nucleotide polymorphism (SNP) arrays. The quality of the data, in general, has passed our standards. The analysis will begin in year 2 and continue into year 3.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA554417

Entities

People

  • John Harley

Tags

DTIC Thesaurus Topics

  • Active Duty
  • African Americans
  • Autoimmune Diseases
  • Availability
  • Biomedical Research
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Ethnic Groups
  • Genes
  • Genetic Markers
  • Genetics
  • Genome
  • Lupus
  • Standards

Readers

  • Neurological Diseases/Conditions/Disorders
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology