Optimization of Assays to Assess Dendritic Cell Activation and/or Energy in Ebola Infection

Abstract

The immune responses during lethal virus infection and the correlates of protective immunity in vaccinated macaques are not well understood. This study aims to develop assays that can predict protection with the various vaccine platforms designed to provide immunity to filovirus (Ebolavirus (EBOV) and Marburgvirus (MARV)) infection. A secondary aim is to better understand the aspects of virus on the immune response in animals that receive no intervention. As part of these efforts, we have in (Task 1) begun to profile the functional and phenotypic status of immune cells in Ebola virus (EBOV)-infected non-human primates and (Task 2) to develop assays that will assess virus-induced immune dysregulation and identify strategies to overcome virusinduced immune dysregulation. The latter work focuses on macrophages and dendritic cells, which are important targets of Ebola viruses in vivo and are thought to mediate dysregulated immunity during infection in vivo 1-4.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA554501

Entities

People

  • Christopher F Basler

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Blood Cells
  • Cells
  • Ebola Virus
  • Immune System
  • Immunity
  • Infection
  • Leukocytes
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Medical Personnel
  • Monocytes
  • Mononuclear Phagocyte System
  • Myeloid Cells
  • Viruses
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology
  • Infectious Disease/Epidemiology
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech