Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury

Abstract

Severe bone loss commonly occurs in individuals with chronic spinal cord injury who are non-weightbearing and leads to an increased risk of lower extremity fractures. This multi-site, double-blind, randomized, placebo-controlled study evaluates the efficacy and safety of two interventions known to be anabolic to bone, parathyroid hormone and mechanical loading (provided as teriparatide and vibration) in 60 SCI individuals with low bone mass. After the first year of this project, all clinical sites have obtained regulatory approval and all preparatory work has been completed. Five participants have been enrolled with 4 additional participants in the run-in phase of the study. No results regarding efficacy or safety of these interventions are yet available.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA554543

Entities

People

  • Thomas J Schnitzer

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Biomedical Research
  • Body Regions
  • Data Management
  • Databases
  • Department Of Defense
  • Health Services
  • Intervention
  • Lower Extremity
  • Medical Personnel
  • Osteoporosis
  • Parathyroid Hormones
  • Spinal Cord
  • Spinal Injuries
  • Vibration
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.