Role of Foxm1 in the Pathogenesis of Prostate Cancer
Abstract
The main purpose of our work is to understand the role of Foxm1 in the development of prostate cancer, provide information about molecular mechanisms whereby Foxm1 controls epithelial cell proliferation during PCa, and determine whether the inhibition of Foxm1 may potentially be beneficial during PCa therapy, therefore leading to the development of the novel therapeutic target for prostate cancer chemotherapy. During the second year of grant support, we demonstrated that the deletion of Foxm1 from prostate epithelial cells reduced prostate carcinogenesis in mouse model. Decreased carcinogenesis in epFoxm1-l-l TRAMP mice was associated with decreased proliferation of tumor cells and reduced expression of cell cycle regulatory genes Cdc25b, Cyclin B1, and Plk-1. Moreover, we demonstrated that Foxm1 directly regulates the expression of VEGF-A expression in prostate tumor cells, suggesting the role of Foxm1 in prostate tumor angiogenesis. Furthermore, our data demonstrated that deletion of Foxm1 from prostate epithelium decreased prostate cancer metastatsis in TRAMP mice. Foxm1 transcription factor regulates several genes during prostate cancer progression and metastatsis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2011
- Accession Number
- ADA554568
Entities
People
- Tanya Kalinichenko