Human Neural Cell-Based Biosensor

Abstract

Human neural progenitor cells have a strong potential for use as cell-based biosensors for environmental toxins. The overall goal of this project is to develop a human neural cell based biosensor using ArunA s neural cell lines. In this report, we detail progress in development for the following areas: (1) neural progenitor isolation from induced pluripotent stem cells, (2) directed differentiation of progenitors into dopaminergic neurons and astrocytes and (3) HTS amenable assays for proliferation, differentiation, cell migration, mitochondrial function, reactive oxygen species generation and apoptosis as sensor elements.

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Document Details

Document Type
Technical Report
Publication Date
Jan 06, 2012
Accession Number
ADA554709

Entities

People

  • Allan Powe
  • Jamie Chilton
  • Steven L. Slice

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Astrocytes
  • Beta Testing
  • Biosensors
  • Cell Line
  • Cell Movement
  • Cells
  • Contracts
  • Department Of Defense
  • Detectors
  • Electronic Mail
  • Instructions
  • Migration
  • Military Research
  • Neurons
  • Neurosciences
  • Stem Cells

Fields of Study

  • Biology
  • Chemistry

Readers

  • Immunology and Pathology
  • Molecular and Cellular Biochemistry
  • Neural Network Machine Learning.

Technology Areas

  • Biotechnology