Estrogen and the Dietary Phytoestrogen Resveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Metastasis
Abstract
The hypothesis that estrogen and low concentrations of resveratrol promote breast cancer invasion and metastasis while high concentrations of resveratrol prevent breast cancer metastasis via regulation of Rac was tested. Results from Specific Aim 1 demonstrated that dependent on estrogen receptor (ER) status, E2 and resveratrol have differential effects on Rac activity, cell migration/invasion, and cell growth. Specific Aim 2, we tested the effect of resveratrol on mammary tumor growth and metastasis. At all concentrations tested, resveratrol increased mammary tumor growth and lung metastasis and enhanced Rac activity. Since the Rac activity of breast cancer cells could not be inhibited by a commercially available Rac inhibitor NSC-23766, we developed novel Rac inhibitors as anti breast cancer metastasis compounds (Hernandez, et al., 2010, Montalvo et al., in review). Resveratrol in combination with other grape polyphenols reduced breast cancer growth and metastasis to bone and liver by inhibition of PI3-K signaling (Castillo et al., 2009; Castillo et al., in review).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2011
- Accession Number
- ADA554793
Entities
People
- Suranganie Dharmawardhane
Organizations
- University of Puerto Rico