Noninvasive Subharmonic Pressure Estimation for Monitoring Breast Cancer Response to Neoadjuvant Therapy
Abstract
Neoadjuvant chemotherapy is currently the standard of care for locally advanced breast cancer (LABC). Monitoring tumor response is advantageous for patients. This project aims at establishing noninvasive monitoring of neoadjuvant chemotherapy in the breast using subharmonic aided pressure estimation (SHAPE) to estimate the interstitial fluid pressure (IFP) in LABC. New in vitro experiments with the ultrasound contrast agent Definity have showed an inverse linear relationship between the change in subharmonic amplitude and hydrostatic pressure (r2 = 0.63 - 0.95, p < 0.01) over the pressure range associated with breast tumors (0 50 mmHg). Moreover, software for analyzing RF data from a Sonix RP scanner to produce SHAPE pressure estimates has been successfully optimized and published. In vivoproof of concept for SHAPE as a noninvasive monitor of IFP (r2 = 0.67 - 0.96, p < 0.01) has been provided based on a swine model. The work on in vivo SHAPE measurements of IFPwas selected for the final of the American Institute of Ultrasound in Medicine (AIUM) 2011 Young Investigator Award (for V. G. Halldorsdottir) and was awarded FIRST place out of 90 abstracts submitted for this competition.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2011
- Accession Number
- ADA555063
Entities
People
- Flemming Forsberg
Organizations
- Thomas Jefferson University