Are Blast Brain Injuries Fundamentally Different Than Traditional Experimental Models of TBI?
Abstract
We compared acute neurophysiological changes in rats following a blast-type TBI induced by a shock tube with more traditional models of TBI, i.e., midline fluid percussion (PERCUSSION) and controlled cortical impact brain injuries. Currently, insufficient data exists which compares the physiological brain changes induced by a blast-type injuries to those generated by more traditional animal models of TBI. We hypothesized in this proposal that brain damage from a blast-type injury (BLAST) may be very similar to those induced by a PERC injury model but fundamentally different than penetrating and ballistic-type brain injuries modeled by a pneumatic piston. We first documented neurophysiological and behavioral changes in rats following graded levels of PERCUSSION injury, which has been submitted for rapid publication in Neurosurgery Focus (see Appendix). In the second year, approved as a no-cost extension , we are analyzing the data for BLAST injuries and comparing where on the severity scale, BLAST brain injuries fall when compared to PERCUSSON injuries of graded intensities.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2011
- Accession Number
- ADA555071
Entities
People
- Stefan Lee
Organizations
- University of Southern California