Methodology Report for H2SModel
Abstract
Hydrogen sulfide is similar in pathophysiology to cyanide in that it binds to mitochondrial cytochrome oxidase. By blocking oxidative respiration at the cellular level its effects are most evident in tissues with high metabolic demand such as the central nervous system, cardiovascular, and respiratory systems. The onset of signs and symptoms is rapid. Hydrogen sulfide also has local irritant effects, particularly upon the nose and membranes of the upper respiratory tract and the eyes. Physiological manifestations of H2S exposure may be quantified as a time-dependent severity vector described as increased time required to perform tasks owing to H2S-induced performance decrements as well as lethality. The model uses the time integral of agent concentration to calculate an internal "dose", then determines the severity vector based on the dose. Outcome probability can be estimated as the time course till the casualty returns to duty, or else dies. Although H2S has not knowingly been used in warfare, it is a toxic industrial chemical/toxic industrial material that could be used as a terrorist agent.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2012
- Accession Number
- ADA555248
Entities
People
- B. Asgharian
- D. Crary
- D. Oldson
- G. Mcclellan
- S. Watson
Organizations
- Applied Research Associates (United States)