Transcriptional Analysis of Rat Piriform Cortex Following Exposure to the Organophosphonate Anticholinesterase Sarin and Induction of Seizures

Abstract

Organophosphorus nerve agent irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. Current medical countermeasureres to nerve agent intoxication increase survival if administered within a short period of time following exposure but may not fully prevent neurological damage. Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2011
Accession Number
ADA555332

Entities

People

  • Christopher L. Robison
  • James F. Dillman Iii
  • James L. Meyerhoff
  • Kimberly D. Spradling
  • Lucille A. Lumley

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Brain Injuries
  • Chemical Compounds
  • Chemical Warfare Agents
  • Chemical Weapons
  • Enzyme Inhibitors
  • Intoxication
  • Nerve Agents
  • Organic Compounds
  • Organophosphates
  • Organophosphorus Compounds
  • Printing
  • Survival

Readers

  • Neuroscience
  • Neurotoxicology