Evaluating the Role of Genetic Markers in Prostate Cancer Progression: A Multiethnic Cohort Experience

Abstract

Most prostate cancer(PCa) research has focused on risk, little is known about predictors of progression and even less about how these factors differ by ethnicity/race. There are strong racial disparities in mortality with African-Americans twice as likely to die from PCa comparedto Caucasians; very little data are available in Hispanics. Our goal was to identify markers of PCa progression in a multiethnic cohort(773 Caucasians, 361 African-Americans & 246 Mexican-Americans). Medical records for all participants have been abstracted, and we have updated vital status using the National Death Index. Using DNA extracted from archived specimens, we utilized a genome wide association study approach to identify polymorphisms associated with PCa progression; this approach has lead to the identification of different polymorphisms to be relevant in Caucasians vs. African- Americans. These results may offer insight into racial/ethnic differences in PCa progression and may be used to develop racespecific models for PCa progression.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA555446

Entities

People

  • Sara Strom

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cardiovascular Physiological Phenomena
  • Chromosomes
  • Databases
  • Ethnic Groups
  • Genetics
  • Health Services
  • Information Science
  • Medical Genetics
  • Medical Personnel

Readers

  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology