Personalized Medicine in Veterans with Traumatic Brain Injuries
Abstract
The study was designed to identify clinically accessible molecular biomarkers of traumatic brain injury (TBI) prior to definitive clinical diagnosis using high throughput microRNA technology. Specifically, these studies will identify, characterize, and validate microRNA biomarker species whose content in peripheral blood mononuclear cells (PBMC) could help to distinguish TBI cases within Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) veteran population. During the past year, we conducted a Biomarker Discovery study using a high-throughput Array chip platform and identified 18 candidate TBI small RNA biomarkers. Moreover, using independent Q-PCR assays, we confirmed that thirteen (13) of these candidate small RNA biomarker species are, indeed, significantly down-regulated in PBMC of TBI compared to non-TBI control veteran cases. Additionally, we use an unsupervised clustering analysis and demonstrated that differential regulations of these small RNA biomarkers in clinically accessible blood cells are capable of dissecting TBI and non-TBI OEF/OIF veteran cases.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2011
- Accession Number
- ADA555685
Entities
People
- Giulio Maria Pasinetti