Purinergic Receptors in Quiescence and Localization of Leukemic Stem Cells

Abstract

A small subpopulation of drug- and radiation-resistant leukemia is an immediate concern for leukemia patients as this subtype remains the actual cause of morbidity and mortality. Our preliminary results showed that P2Y14 functions in bone marrow to preserve stem progenitor cells from premature senescence/cell death induced by genotoxic stress. As P2Y14 is highly expressed in differentiation resistant leukemia cells, P2Y14 expression in leukemia cells may function in preserving regenerative capacity by constraining cell death/senescence induction. We also found that P2Y14 axis is associated with stem cell mobilization. By providing a mechanistic insight for the roles of P2Y14 in the genotoxic stress-induced injury, directly documenting the effects of P2Y14/UDP-Glc axis on stem cell mobilization, our preliminary results are expected to provide the foundation for an effective treatment to destroy therapy resistant leukemia cells.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2011
Accession Number
ADA555803

Entities

People

  • Byeong-chel Lee

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Biological Aging
  • Biomedical Research
  • Blood
  • Blood Cells
  • Bone Marrow
  • Bone Marrow Cells
  • Bones
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Genes
  • Mobilization
  • Neoplasms
  • Radiation
  • Stem Cells

Readers

  • Immunology
  • Immunology and Pathology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology