Medial Prefrontal Cortex and HPA Axis Roles in Generation of PTSD-Like Symptoms in SPS Model

Abstract

The research we have conducted over the third year of this research program is contained in this report. We have made substantial progress towards completing all of the proposed research in this program within proposed time frame i.e. final report on 9/29/12. During the last year, we have demonstrated that (1) decreases in neural activity in the BLA and hippocampus are critical for SPS-enhanced fear renewal (specific aims #1a and b), (2) have linked SPS-enhanced glucocorticoid receptor expression to SPS-induced extinction recall deficits (specific aim #1c), (3) demonstrated that the BLA is critical for social interactions (specific aim #2), and (4) demonstrated that SPS induces cognitive deficits, which may be relevant to emotional regulation (specific aim #3).

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA555896

Entities

People

  • Dayan Knox
  • Israel Liberzon
  • Sophie George

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Anesthesia
  • Anxiety Disorders
  • Body Weight
  • Brain
  • Chemical Reactions
  • Chemistry
  • Cognition
  • Data Analysis
  • Diseases And Disorders
  • Experimental Design
  • Hydroxides
  • Medical Personnel
  • Neurosciences
  • Psychiatry
  • Surgery
  • Traumatic Stress Disorder

Readers

  • Neuroscience
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.