Characterization of IKBKE as a Breast Cancer Oncogene

Abstract

A summary is presented of research performed during three years of a project to further characterize the breast cancer oncogene IKK(epsilon). Two specific aims were pursued. The first was to determine the role of ubiquitination in the upstream regulation of IKK(epsilon). The second aim created a mammary-specific constitutive IKK(epsilon) transgenic mouse model to study the role of IKK(epsilon) in breast cancer initiation and maintenance. The long term goals of this research were to elucidate the mechanism of IKK(epsilon) upstream regulation in order to better understand how it is dysregulated and overexpressed in human breast cancer and also to create a genetic animal model of IKK(epsilon) breast cancer initiation for further study.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA555899

Entities

People

  • Alicia Zhou

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Epithelial Cells
  • Families (Human)
  • Kinases
  • Maintenance
  • Mammary Glands
  • Mass Spectrometry
  • Neoplasms
  • Proteins
  • Spectrometry
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.

Technology Areas

  • Biotechnology