Treatment of TBI and Concomitant Hemorrhage with Ghrelin

Abstract

Novel therapeutic advances in the field of trauma management depend upon animal models that can accurately predict the clinical efficacy of interventions. In the battlefield, traumatic brain injury (TBI) and hemorrhagic shock often occur concomitantly due to multiple injuries. In this project, we determined the long-term effect of ghrelin, a 'gut-brain' hormone, in a highly military relevant experimental rat model of TBI combined with uncontrolled hemorrhagic shock. Our results showed that ghrelin improves long-term brain function, prevents weight loss and decreases mortality after traumatic brain injury and uncontrolled hemorrhagic shock. Thus, ghrelin can be further developed as a safe and effective resuscitation approach for the trauma victim with brain injury and severe blood loss.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2011
Accession Number
ADA555907

Entities

People

  • Lei S Qi
  • Rongqian Wu
  • Xioaxuan Cui

Organizations

  • The Feinstein Institute for Medical Research

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Battlefields
  • Biomedical Research
  • Body Weight
  • Brain Injuries
  • Combat Casualty Care
  • Department Of Defense
  • Hemorrhage
  • Hemorrhagic Shock
  • Resuscitation

Fields of Study

  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Neurotrauma and Rehabilitation Medicine.