Label Structured Cell Proliferation Models

Abstract

We present a general class of cell population models that can be used to track the proliferation of cells which have been labeled with a fluorescent dye. The mathematical models employ fluorescence intensity as a structure variable to describe the evolution in time of the population density of proliferating cells. While cell division is a major component of changes in cellular fluorescence intensity, models developed here also address overall label degradation.

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Document Details

Document Type
Technical Report
Publication Date
Jun 16, 2010
Accession Number
ADA556904

Entities

People

  • Frederique Charles
  • H. Thomas Banks
  • Karyn L. Sutton
  • Marie D. Jauffret
  • W. C. Thompson

Organizations

  • North Carolina State University

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Cell Division
  • Cells
  • Coordinate Systems
  • Data Sets
  • Degradation
  • Differential Equations
  • Equations
  • Experimental Data
  • Fluorescence
  • Fluorescent Dyes
  • Intensity
  • Inverse Problems
  • Mathematical Models
  • Measurement
  • Models
  • Physical Properties

Fields of Study

  • Biology
  • Mathematics

Readers

  • Chemistry (specifically Chemical Fluorescence)
  • Computational Modeling and Simulation
  • Oncology (Cancer Research).