Selected Vapor Phase Sensing of Small Molecules Using Biofunctionalized Field Effect Transistors

Abstract

This work details a proof of concept study for vapor phase selective sensing using a strategy of biorecognition elements (BRE) integrated into a zinc oxide field effect transistor (ZnO FET). ZnO FETs are highly sensitive to changes to the environment with little to no selectivity. Addition of a biorecognition element retains the sensitivity of the device while adding selectivity. The DNA aptamer designed to bind the small molecule riboflavin was covalently integrated into the ZnO FET and detects the presence of 116 ppb of riboflavin in a nitrogen atmosphere by a change in current. The unfunctionalized ZnO FET shows no response to this same concentrations of riboflavin, showing that the aptamer-binding strategy may be a promising strategy for vapor phase sensing.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2012
Accession Number
ADA557305

Entities

People

  • Joshua A Hagen
  • Morley O. Stone
  • Nancy Kelley-Loughnane
  • Rajesh R Naik
  • Sang N. Kim

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Advanced Electronics

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Detection
  • Elements
  • Field Effect Transistors
  • Mass Spectrometry
  • Materials Laboratories
  • Molecules
  • Nanotechnology
  • Nitrogen
  • Phase
  • Semiconductors
  • Small Molecules
  • Surface Plasmon Resonance
  • Surface Plasmons
  • Transistors
  • Vapor Phases

Readers

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