The Mediation Formula: A Guide to the Assessment of Causal Pathways in Nonlinear Models

Abstract

Mediation analysis aims to uncover causal pathways along which changes are transmitted from stimulus to response. Recent advances in causal inference have given rise to a general and easy-to-use estimator for assessing the extent to which the effect of one variable on another is mediated by a third, thus setting a causally-sound standard for mediation analysis of empirical data. This estimator, called Mediation Formula, is applicable to nonlinear models with both discrete and continuous variables, and permits the evaluation of path-specific effects with minimal assumptions regarding the data-generating process. We demonstrate the use of the Mediation Formula in simple examples and illustrate why parametric methods of analysis yield distorted results even when parameters are known precisely. We stress the importance of distinguishing between the necessary and sufficient interpretations of "mediated-effect" and show how to estimate the two components in systems with categorical variables, including logistic, probit, and non- parametric regressions.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 27, 2011
Accession Number
ADA557435

Entities

People

  • Judea Pearl

Organizations

  • University of California, Los Angeles

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Artificial Intelligence
  • Causal Reasoning
  • Clinical Trials
  • Educational Psychology
  • Linear Systems
  • Mediation
  • New York
  • Nonlinear Dynamics
  • Nonlinear Systems
  • Psychology
  • Reasoning
  • Social Psychology
  • Social Sciences
  • Standards
  • Statistical Inference
  • Statistics
  • Test And Evaluation

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Regression Analysis.

Technology Areas

  • AI & ML
  • AI & ML - Bayesian Inference