Effects of Oral Guanidinium 3,4-dinitropyrazolate (GDNP) Exposure to Female Rats (Rattus norvegicus)
Abstract
The Army Environmental Quality Technology Program (EQT) Ordnance Environmental Program (OEP) is dedicated to finding replacements for RDX that will reduce or eliminate the health risks from environmental exposure and will reduce adverse ESOH effects and effects of RDX on readiness and costs associated with training. USARDECOM-sponsored work with Physical Sciences Inc. (Andover, MA) and BAE Ordnance Systems (Kingsport, TN) developed GDNP as a possible replacement for RDX. This document reports the conduct, findings, and conclusions of a progressive series of two oral toxicity studies performed with GDNP in laboratory female rats. The LD50 in female rats in tap water solution if 720 mg/kg. Daily oral exposure to 500 mg/kg-d of GDNP for 14-days causes weight loss, increased liver and spleen organ weights, and adverse histopathologic events in kidney and spleen. These adverse events were not observed in animals receiving lower doses of GDNP is low and is not limiting to the continued development of GDNP.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2012
- Accession Number
- ADA557438
Entities
People
- Dawn Fitzhugh
- Larry Williams
- Lee Crouse
- Rebecca Kilby
- Robert Sunderland
- Shannon Wallace
- Theresa Hanna
- Valerie Adams
- Wilfred Mccain
- William Eck
Organizations
- Physical Sciences (United States)