Transforming Growth Factor Beta Signaling in Growth of Estrogen-Insensitive Metastatic Bone Lesions

Abstract

While many women with breast cancer will use estrogen receptor therapeutics such as fulvestrant, resistance is nearly inevitable. Recently, it has been noted that the epidermal growth factor receptor (EGFR) family plays a vital role in metastasis to bone; also cross signaling with the transforming growth factor receptor type II (TGFBR2) has been noted to increase levels of destructive environmental cytokines. Therefore we are examining the role of EGFR/TGFBR2 cross talk in bone metastatic breast cancer. The study of these pathways are important to metastatic breast cancer, as they have been known to increase levels of the destructive cytokine parathyroid hormone related protein (PTHrP), which causes increased osteolysis within the bone environment. To elucidate the connection between these two vital receptors may led to further progression in therapeutics for those women with EGFR positive tumors.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2012
Accession Number
ADA558405

Entities

People

  • Nicole Nickerson

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Peptide Growth Factors
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).
  • Systems Analysis and Design