Improvements in Diagnostic Accuracy with Quantitative Dynamic Contrast-Enhanced MRI

Abstract

We developed novel calibration phantoms that when placed in a breast coil during a routine dynamic contrast enhanced MRI of the breast allow for the acquisition of quantitative images displaying the concentration of contrast media as well as MRI-detectable proton density. To date 21 patients have been scanned with the phantoms. Preliminary results suggest a differentiation between benign and malignant lesion by peak concentration of contrast media. A study is under way to determine whether these methods eliminate any variability seen across two different field strengths, 1.5T and 3T. These methods also allow for pharmacokinetic modeling, which will lead to physiological parameters that have been shown to be diagnostically useful.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2011
Accession Number
ADA558442

Entities

People

  • Federico Pineda

Organizations

  • University of Chicago

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biomedical Research
  • Breast Cancer
  • Calibration
  • Cancer
  • Carcinoma
  • Contrast
  • Contrast Media
  • Department Of Defense
  • Electronic Mail
  • Heavy Water
  • High Resolution
  • Low Resolution
  • Menstrual Cycle
  • Models
  • Neoplasms
  • Water

Fields of Study

  • Medicine
  • Physics

Readers

  • Computational Modeling and Simulation
  • Medical Imaging.