Magnetic Resonance Characterization of Axonal Response to Spinal Cord Injury

Abstract

Spinal cord injuries (SCI) produce direct mechanical disruption and subsequent severe degeneration of axons; these processes cause the associated neurologic deficits. Histological studies of fixed tissue in animal models of SCI have described axonal loss and demyelination. Research at the U. Penn site brings novel magnetic resonance methodology to bear with the objective of obtaining quantitative information on axonal degeneration and myelin loss following SCI in a mouse model by pursuing the following specific aims per the work statement: 1. We will perform q-space MR imaging (QSI) and simulations of QSI to quantify axonal architecture in healthy and injured mouse spinal cords. 2. We will quantify myelin content with three quantitative MRI techniques in healthy and injured mouse spinal cords and compare the results with histology.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA558688

Entities

People

  • Alan Tessler

Organizations

  • Drexel University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Department Of Defense
  • Electronic Mail
  • High Resolution
  • Imaging Techniques
  • Information Operations
  • Intensity
  • Magnetic Resonance
  • Pilot Studies
  • Resonance
  • Sequences
  • Simulations
  • Spinal Cord
  • Spinal Injuries
  • Surface Waters

Readers

  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Space