Tissue and Circulating Expression of IL-1 Family Members Following Heat Stroke

Abstract

Interleukin-1 (IL-1) is thought to have a significant role in the pathophysiology of heat stroke (HS), although little is known regarding the actions or expression patterns of the IL-1 family. This study tested the hypotheses that following HS IL-1 family gene expression is dynamic, while loss of IL-1 signaling enhances recovery. IL-1 family expression was determined in plasma, spleen, and liver from C57BL/6J mice (n = 24 control, n = 20 HS) at maximum core temperature (Tc,Max), hypothermia, and 24 h post-HS (24 h). Soluble IL-1 receptor subtype I (sIL-1RI) protein expression peaked at 24 h (14,659.01 + 2,016.28 pg/ml, P < 0.05), while sIL-1RII peaked at hypothermia (19,099.30 + 1,177.07 pg/ml). IL-1 alpha gene expression in the spleen (ninefold) and liver (fourfold) along with IL-1RI (threefold spleen and fivefold liver) were maximal at hypothermia. Spleen IL-1 alpha gene expression peaked at Tc,Max (fourfold) but at hypothermia (fourfold) in liver. Gene expression of the IL-1 family member IL-18 peaked (2.5-fold) at Tc,Max but was similar at all other time points.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2011
Accession Number
ADA558998

Entities

People

  • Bryan G. Helwig
  • Lisa R. Leon

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anesthesia
  • Blood
  • Brain
  • Cells
  • Central Nervous System
  • Data Analysis
  • Data Science
  • Department Of Defense
  • Environment
  • Gene Expression
  • Heat Stroke
  • Lymphatic System
  • Lymphocytes
  • Measurement
  • Peptide Growth Factors
  • Rodents
  • Statistical Analysis

Fields of Study

  • Medicine

Readers

  • Aviation Safety and Air Traffic Management
  • Immunology and Pathology
  • Mathematics or Statistics