Theory-Driven Models for Correcting Fight or Flight Imbalance in Gulf War Illness

Abstract

The objective of this study is to create a comprehensive engineering model of endocrineimmune interaction dynamics in order to identify (i) theoretical failure modes of the HPAimmune axis that align with GWI, and (ii) promising treatment strategies that exploit the regulatory dynamics of these systems to reset control of the HPA-immune axis to normal. We have completed the negotiation of sub-awards to the CFIDS Association of America, the university of Miami and Ohio State University. The ratification of these inter-institution agreements required more time than originally anticipated and on August 29, 2011 we requested a one-year extension without additional funding to adjust for this delay. Some limited preliminary work was nonetheless conducted. We are recruiting a new senior research associate and expect no further delays.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2011
Accession Number
ADA559085

Entities

People

  • Gordon Broderick
  • N. G. Klimas
  • S. D. Vernon
  • V. Folcik

Organizations

  • University of Alberta

Tags

Communities of Interest

  • C4I
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Anesthesia
  • Department Of Defense
  • Diseases And Disorders
  • Engineering
  • Failure Mode And Effect Analysis
  • Mathematical Models
  • Medical Personnel
  • Molecular Dynamics
  • Molecular Mechanics Methods
  • Neurodegeneration
  • Parkinson'S Disease
  • Physics
  • Psychology
  • Schools
  • Students
  • Traumatic Stress Disorder

Readers

  • Clinical Trial Research.
  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Joint Military Operations and Doctrine.