Degradable Bone Graft Substitute for Effective Delivery of Multiple Growth Factors in the Treatment of Nonunion Fractures

Abstract

During this reporting period, a more general set of hydrogel synthesis steps were defined which enables the incorporation of chitosan from multiple sources and suppliers and still produce a consistent material. Functional behavior of the hydrogel was confirmed with a new source of chitosan, inducing tissue ingrowth into a subcutaneously injected scaffold loaded with the composite xylan/chitosan hydrogel. Delivery of new hydrogel treatment for tibia fractures was accomplished with the xylan/chitosan composite showing bioactivity even in the absence of therapeutic proteins. Fractures treated with the xylan/chitosan composite showed accelerated remodeling of the fracture callus to normal bone compared to a hydrogel without the xylan component. No mineralization in response to treatment with BMP-4 has been observed in subcutaneous models, therefore activity is being tested with positive controls. Demonstration of non-union defect in rodent femur has been accomplished. Femoral fracture study in rats is now underway.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA559323

Entities

People

  • Joshua Bush

Organizations

  • University of Virginia

Tags

DTIC Thesaurus Topics

  • Biocompatible Materials
  • Biomedical Research
  • Blood Vessels
  • Bone Fractures
  • Composite Materials
  • Engineering
  • Growth Factors
  • Hydrogels
  • Instructions
  • Materials
  • Osteogenesis
  • Patent Applications
  • Peptide Growth Factors
  • Polysaccharides
  • Tissue Donors
  • United States
  • X Rays

Readers

  • Trauma Surgery or Emergency Medicine.