Identification of Dormant Stem Cell in Prostate Cancer
Abstract
Recurrent disease is the most daunting aspect of cancer therapy; however, how tumor cells become dormant and later recur is poorly understood. It is of paramount importance to decipher the underlining molecular mechanism of dormancy in order to define specific targets for the treatment of recurrent metastatic disease. The overall goal of this project is to identify key factor(s) and signaling that control tumor stem cell dormancy. In this fiscal year, we have established a unique model of tumor dormancy and recurrence in vivo using CSCs of prostate cancer cell line. This model provides us with an excellent tool to explore the molecular mechanism of tumor cell dormancy of CSCs in prostate cancer in bone. In the next fiscal year, we plan to define the roles of SPARC and Noggin in controlling bone microenvironment for dormancy and recurrence and we have already obtained approval of no-cost extension of this grant. We believe that the results of our experiments will provide important clues to identify specific targets for recurrent prostate tumor so that we can confine metastasized tumor to dormant state.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2012
- Accession Number
- ADA559377
Entities
People
- Kounosuke Watabe
Organizations
- Southern Illinois University