Human Neural Cell-Based Biosensor
Abstract
As a more biologically relevant model of human physiology, human neural progenitor cells have a strong potential as in vitro, cell-based biosensors for environmental toxins. The overall goal of this project is to develop a human neural cell based biosensor using ArunA s neural cell lines. ArunA s neural cell lines, hNP(trademark) Human Neural Progenitor Cells and hN(trademark) Differentiated Neuronal Cells, are derived from human embryonic stem cells (hESC), and more recently ArunA s neural cells lines are being derived from human induced pluripotent stem cells (hiPSC). This report describes progress in these major areas: (1) production of induced pluripotent stem cell derived neural progenitor cells, (2) directed differentiation of progenitors into dopaminergic neurons and astrocytes and (3) assay development of ArunA s neural cell lines as sensor elements for neurotoxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 11, 2012
- Accession Number
- ADA559383
Entities
People
- Jamie Chilton
- Steven L. Stice