Early Detection Of Breast Cancer using Post-Translationally Modified Biomarkers

Abstract

In this project, we focus on oxidation and glycosylation PTMs on proteins known to be secreted by the breast as candidate biomarkers for the early detection of breast cancer. ELISA microarray technology is employed to evaluate assays that have potential be used as breast cancer biomarkers. During the second year of this project we have continued the validation for our PTM-ELISA microarray. Overall, our data suggest that the PTM ELISA microarray platform is a promising tool for discovery and evaluation of biomarkers that have potential for the early detection of breast cancer. Besides the post-translational modification, we also investigated post-transcription factors (microRNAs) for breast cancer studies. Our studies suggested that microRNAs may be a potential promising biomarkers for breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2012
Accession Number
ADA559414

Entities

People

  • Hongjun Jin

Organizations

  • Battelle Memorial Institute

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Biomedical And Dental Materials
  • Biomedical Research
  • Blood
  • Blood Proteins
  • Breast Cancer
  • Cell Line
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Department Of Defense
  • Detection
  • Epithelial Cells
  • Peptides
  • Polymer Chemistry
  • Proteins

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Oncology and Biomarker-Based Cancer Detection.