Neural Plasticity and Neurorehabilitation Following Traumatic Brain Injury

Abstract

Rehabilitation following traumatic brain injury is not well understood and has relied primarily on findings from studies conducted in stroke. We have demonstrated that following CCI (a rodent model of contusion TBI), behavioral function was most enhanced by combining 3 types of forelimb rehabilitation: tray reaching, exercise, and forelimb constraint. This enhancement was seen in tests of Forelimb Reaching, Coordination, and Forelimb Use. Combining all three rehabilitation therapies also enhanced performance on rehabilitation tasks. CCI results in a drastic loss of movement representations in the motor cortex, an effect far more severe than expected based on stroke models. Despite this, the motor cortex near the contusion maintains the capacity for motor map plasticity.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2011
Accession Number
ADA559719

Entities

People

  • Dorothy Kozlowski

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animal Structures
  • Brain
  • Brain Injuries
  • Department Of Defense
  • Diseases And Disorders
  • Electron Microscopy
  • Medical Personnel
  • Neuroplasticity
  • Neurosciences
  • Parkinson'S Disease
  • Plastic Properties
  • Psychology
  • Rehabilitation
  • Therapy
  • Transmission Electron Microscopy
  • Wounds And Injuries

Fields of Study

  • Psychology

Readers

  • Neural Network Machine Learning.
  • Neurotrauma and Rehabilitation Medicine.
  • Underwater engineering and Marine Technology.