Genome Wide Association Study to Identify SNPs and CNPs Associated with Development of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy
Abstract
The hypothesis that forms the basis for this research is that patients who possess certain SNPs or CNPs are at a greater risk for developing severe urinary morbidity or ED resulting from radiotherapy for prostate cancer. The specific aim of this project is to identify through a genome wide association study the SNPs and CNPs associated with the development of severe urinary morbidity and ED resulting from the use of radiation to treat prostate cancer. It should be noted that we may also identify SNPs or CNPs that are associated with protection against the development of these forms of radiation injury. Through the end of the project at the NYUMC site, substantial progress was made on the validation phase of the project. This included selection of approximately 5,000 SNPs and CNPs from the discovery phase of the GWAS for genotyping of the 600 samples that comprise the validation cohort. The genotyping and analysis are now being completed through a no-cost extension of the project at the Mount Sinai site.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2011
- Accession Number
- ADA560527
Entities
People
- Barry S. Rosenstein
- Harry Ostrer
Organizations
- New York University