Role of Cyclin E as an Early Event in Ovarian Carcinogenesis

Abstract

At the genetic level, ovarian cancer is characterized by a large degree of genetic instability. High copy-number amplification at the CCNE1 (cyclin E) gene locus is the single most notable recurrent change, occurring in about 20% of tumors. We have hypothesized that CCNE1 gene amplification is an initiating event in the carcinogenic process of a subset of epithelial ovarian cancers. We have made progress towards testing our hypothesis of cyclin E-induced ovarian cancer initiation in a mouse model. We have also demonstrated the mechanisms underlying the synergistic cytotoxicity of ovarian cancer cells to combination treatment with bortezomib and a natural dietary phytochemical indole-3-carbinole (I3C). The translational relevance could be in the re-introduction of bortezomib to the therapeutic armamentarium against ovarian cancer if the in vitro results replicate in humans.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2012
Accession Number
ADA560529

Entities

People

  • Christine Walsh

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cytoskeleton
  • Gene Expression
  • Genetics
  • Health Services
  • Mass Spectrometry
  • Neoplasms
  • Ovarian Cancer
  • Phytochemicals
  • Proteins
  • Proteomics
  • Surgery

Fields of Study

  • Biology

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology