Photonic Breast Tomography and Tumor Aggressiveness Assessment
Abstract
The tasks performed and the progresses made during the fourth year include: (a) carrying out research on development of non-invasive near-infrared (NIR) diffuse optical imaging (DOI) approaches for detection of breast tumors in early stages of growth when those are more amenable to treatment; and (b) training of CCNY researchers at MSKCC in magnetic resonance spectroscopic imaging (MRSI) for detectionof lactate in tumors. The NIR optical imaging research involved: (i) development of time reversal optical tomography (TROT) approach for imaging of single absorbing and single scattering targets as a function of position, and two targets as a function of separation between them;(ii) adaptation and comparison of Principal Component Analysis (PCA) and Non-negative Matrix Factorization (NMF)methods to DOI problem and comparing those with previouslydeveloped OPTICA (optical tomography using independent component analysis). These approaches were demonstrated to be suited for detecting and locating small targets in tissue-simulating turbid media. MRSI investigation of lactate holds promise for assessment of tumor aggressiveness. A new research pre-proposal was developed and submitted to CDMRP 2011 BCRP Idea Award category for funding.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2011
- Accession Number
- ADA560600
Entities
People
- Binlin Wu
- J. A. Koutcher
- M. Alrubaiee
- Swapan K. Gayen
- X. Ni
Organizations
- City University of New York