Hematopoiesis Primer Modeling Combined Injury

Abstract

This report is an overview of the basic principles underlying the formation, function, and response to injury of the different elements of the hematopoietic system. The adverse effects of radiation on the hematopoietic system differ from those of thermal burn or traumatic wounding. In turn, the effects of burn injury and trauma with hemorrhage differ from one another. Accordingly, the effects of individual injurious modality on each hematopoietic element are considered. The cell kinetics of myelopoiesis under irradiation are used in the current model of Radiation-Induced Performance Decrement (RIPD) to estimate lethality. This report is also intended to highlight potential roles for hematopoietic effects in the new models of RIPD to incorporate findings in recent assessments of changes of blood cells in combined injury models (combined injury being defined as radiation injury plus burn or wound trauma injury, or both).

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2012
Accession Number
ADA560653

Entities

People

  • Glen I. Reeves
  • Terry C. Pellmar

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Bone Marrow Cells
  • Cardiovascular System
  • Cells
  • Health Services
  • Hematopoiesis
  • Hemorrhage
  • Hemorrhagic Shock
  • Lymphatic System
  • Lymphocytes
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Nuclear and Radiation Engineering.
  • Trauma or Military Medicine