Quantitative Tractography and Volumetric MRI in Blast and Blunt Force TBI: Predictors of Neurocognitive and Behavioral Outcome

Abstract

Our primary aims have been to determine whether frontal WM microstructural integrity accounts for disparate cognitive outcomes in executive function following mild TBI (mTBI) and to determine if injury severity, as measured by loss of consciousness (LOC), is related to neuropsychological outcome and WM microstructural integrity. We examined a subgroup of mTBI participants with executive dysfunction and compared them to a group with intact executive functioning on DTI measures. Results showed that those with executive dysfunction showed significantly decreased fractional anisotropy (FA) values in the anterior corpus callosum as well as in the cingulum and prefrontal white matter regions. Additionally, across the entire sample, we have found that white matter integrity is strongly associated with performance on executive function measures. Finally, those participants with LOC revealed a higher proportion of executive impairment and a similar regional pattern of decreased FA, with additional group differences in the splenium of the corpus callosum.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2011
Accession Number
ADA560750

Entities

People

  • Lisa Delano-wood

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anisotropy
  • Biomedical Research
  • Brain
  • Cognition
  • Consciousness
  • Data Analysis
  • Department Of Defense
  • Dysfunction
  • Executives
  • Genetic Testing
  • Genetics
  • Institutional Review Board
  • Mental Processes
  • Psychological Phenomena And Processes

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.