Green Tea Modulation of Obesity and Breast Cancer Risk
Abstract
Breast cancer continues to be the most common and second deadliest cancer of women living in the United States.1, 2 It is thought that obesity and chronic inflammation play an important role in increasing risk of breast cancer in humans. 3-5 There is evidence suggesting change in dietary habits including drinking green tea may modify the risk of breast cancer development. This decrease in breast cancer risk may be mediated through the proposed effect of green tea intake on body weight and inflammation. 6, 7 The purpose of this training grant is to examine the effects of green tea extract supplementation for one year on obesity-related hormones and inflammatory biomarkers as two of the purported mechanisms by which green tea may result in reducing breast cancer risk. This research study is a randomized, placebo-controlled, doubleblind in a subgroup of 300 healthy postmenopausal obese and overweight women with differing COMT genotypes of the parent grant called Green Tea and Reduction of Breast Cancer Risk . A major up-to-date achievement of this study includes completing the study for 114 subjects. This accounts for 38% of the total sample size. Another achievement includes recruiting and randomizing 108 more subjects into the study. It is anticipated that the recruitment for this training grant will be finished by the end of July 2012. Finally, the analyses of all biological samples are scheduled to take place at the beginning of April 2012.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2012
- Accession Number
- ADA560852
Entities
People
- Hamed Samavat
Organizations
- University of Minnesota