Regulation of the Prostate Cancer Tumor Microenvironment
Abstract
Toll-like receptors (TLRs) are key signaling molecules that regulate innate and adaptive immune responses to the presence of pathogens. The role of TLRs in cancer is unclear. During our first year of this training proposal, we are expanding transgenic and transgenic crosses to various TLR signaling molecules for Specific Aims 1 and 2. We have generated TRAMP Tg+/- x MyD88-/- mice. Initial results reveal that de novo prostate cancers in absence of MyD88 are larger with higher grade adenocarcinomas than wild-type controls. Analysis of tumor infiltrating cells reveals increased infiltrating macrophage lineage in the absence of MyD88. We are in the process of understanding the activation of signaling pathways, local and systemic cytokine levels, and other infiltrating cell types that may modulate the differences in tumor development. We are also isolating TRAMP Tg/- cell lines deficient in MyD88 to ascertain the role of MyD88 in the intrinsic growth of TRAMP prostate cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2012
- Accession Number
- ADA560887
Entities
People
- Arnold I. Chin
Organizations
- University of California, Los Angeles