Abnormal Vestibulo-Ocular Reflexes in Autism: A Potential Endophenotype

Abstract

The overarching objective of this study is to characterize abnormalities of vestibulo-ocular reflexes (VOR) in Autism Spectrum Disorder (ASD). Specific Aim 1: Characterize horizontal VOR post-rotary nystagmus without optokinetic feedback using a velocity step test. We hypothesize that in ASD vertical eye movement intrusions during horizontal nystagmus will occur more frequently than normal, will be time-locked to horizontal nystagmus, and will differ from voluntary saccades. Specific Aim 2: Characterize horizontal VOR without optokinetic feedback using sinusoidal oscillation tests. We hypothesize that gain and phase lag of horizontal VOR will differ in children with ASD compared to controls. Specific Aim 3: Characterize in ASD vertical VOR and torsional VOR, both without optokinetic feedback. Because neither of these aspects of the VOR have been described previously in ASD, Aim 3 is exploratory.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2011
Accession Number
ADA561069

Entities

People

  • Keith White

Organizations

  • University of Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Autism
  • Brain
  • Central Nervous System
  • Databases
  • Diseases And Disorders
  • Human Behavior
  • Institutional Review Board
  • Magnetic Resonance
  • Nervous System
  • Neurosciences
  • Pilot Studies
  • Psychiatry
  • Psychological Tests
  • Psychology
  • Rehabilitation
  • Video Cameras

Fields of Study

  • Biology
  • Medicine

Readers

  • Aviation Safety and Air Traffic Management
  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.