Canonical Wnt Signaling as a Specific Marker for Normal and Tumorigenic Mammary Stem Cells

Abstract

We have determined that the Wnt/B-catenin signaling pathway is active within a small subset of cells within the mammary gland. This small subset is entirely contained within the previously identified population that has the ability to repopulate a cleared mammary fat pad. Thus, activation of canonical Wnt signaling may be a very specific marker for mammary stem cells and be a target for transformation that results in the formation of aggressive mammary tumors.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2012
Accession Number
ADA561084

Entities

People

  • Bart Williams

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Staining And Labeling
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Department Of Defense
  • Dermatologic Agents
  • Electronic Mail
  • Epithelial Cells
  • Epithelium
  • Gene Expression
  • Glands
  • Information Operations
  • Mammary Glands
  • Neoplasms
  • Stem Cells

Fields of Study

  • Biology
  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology