Oxidative Stress, DNA Repair, and Prostate Cancer Risk

Abstract

Oxidative stress, which results from an imbalance between ROS and antioxidant capacities, can cause a wide range of direct or indirect DNA damage. There are extensive DNA repair systems that can correct DNA damage caused by ROS before cell replication and mutation fixation. Although oxidative stress appears to be important in the etiology of prostate cancer, so far there is no study to comprehensively investigate the association between DRC of oxidative DNA damage as a phenotype and prostate cancer risk. We hypothesize that DRC of oxidative DNA damage as a phenotype may modify prostate cancer risk. We have completed the analysis of DRC in 350 prostate cancer patients and 350 healthy controls. Overall, we didn t observe any significant association between DRC and prostate cancer risk. Therefore, we have concluded that DRC is not a risk factor for prostate cancer

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2011
Accession Number
ADA561087

Entities

People

  • Hua Zhao

Organizations

  • Health Research, Incorporated

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Antioxidants
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cells
  • Department Of Defense
  • Instructions
  • Intensity
  • Lymphocytes
  • Neoplasms
  • Oxidative Stress
  • Phenotypes
  • Prostate
  • Prostate Cancer
  • Risk Factors
  • Tissue Extracts

Fields of Study

  • Biology

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Molecular Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology